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KMID : 0389420130210040330
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Korean Journal of Stress Research
2013 Volume.21 No. 4 p.330 ~ p.337
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Association between Exonic SNPs of TLR5 and Benign Prostate Hyperplasia in Korean Population
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Seok Ho-Sik
Lee Byung-Cheol
Kim Young-Ock
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Abstract
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Benign prostatic hyperplasia (BPH) is prevalent in aging male, and it is increasing in Korean male. Factors affecting BPH development include family history. Toll-like receptor (TLR) 5 is a major part of innate immune, and it may contribute to the immunologic responses linked to the BPH pathophysiology. To investigate the genetic effect of the TLR5 polymorphisms on the development and clinical features of BPH, three missense single nucleotide polymorphisms (SNPs) of TLR5 (rs5744168, rs5744174, rs2072493) were tested in 219 BPH and 211 control subjects. The SNPs were genotyped and statistically analysed in multiple logistic regression analysis. rs5744174 was significantly associated with BPH in genotype analysis (codominant2, OR=9.60, p=0.005; recessive, OR=9.15, p=0.001; and log-additive, OR=1.56, p=0.018). rs2072493 was significantly associated with BPH (codominant1, OR=0.65, p=0.042; dominant, OR=0.63, p=0.022; log-additive, OR=0.69, p=0.018; and allele frequencies, OR=0.70, p=0.02). In conclusion, we suggest that TLR5 polymorphisms may be associated with BPH, and that rs5744174 and rs2072493 may be associated with the development of BPH. This study has some limitation, therefore further studies with larger sample size and other populations will be needed to verify our results.
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KEYWORD
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Benign prostatic hyperplasia, TLR5, Single nucleotide polymorphism
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